N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide

Base Information

Chemical Name:N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide
CAS No.:1428746-14-8
Molecular Formula:C₂₉H₂₅NO₅
Molecular Weight:467.521
Hs Code.:

Synonyms:N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide

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Chemical Property of N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide

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Technology Process of N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide

There total 4 articles about N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1428746-32-0
N-(2-acetyl-3-oxo-1-phenylbutyl)acrylamide

: 100-83-4
meta-hydroxybenzaldehyde

: 1428746-14-8
N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide

Guidance literature:: N-(2-acetyl-3-oxo-1-phenylbutyl)acrylamide; With boron trioxide; In N,N-dimethyl-formamide; at 75 ℃; for 0.5h; Inert atmosphere;

meta-hydroxybenzaldehyde; With boric acid tributyl ester; In N,N-dimethyl-formamide; for 0.0833333h; Further stages; Inert atmosphere;
DOI:10.1002/ardp.201700005

Reference yield: 50.0%

: 1428746-32-0
N-(2-acetyl-3-oxo-1-phenylbutyl)acrylamide

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1428746-14-8
N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide

Guidance literature:: N-(2-acetyl-3-oxo-1-phenylbutyl)acrylamide; 4-hydroxy-benzaldehyde; With boron trioxide; boric acid tributyl ester; In N,N-dimethyl-formamide; at 75 ℃; for 0.0833333h; Inert atmosphere;

With morpholinium chloroacetate; at 75 ℃; for 3h; Inert atmosphere;

With water; acetic acid; at 20 - 75 ℃;

Reference yield:

: 123-54-6,81235-32-7
acetylacetone

: 1428746-14-8
N-((E)-5-(3-hydroxyphenyl)-2-((E)-3-(3-hydroxyphenyl)acryloyl)-3-oxo-1-phenylpent-4-en-1-yl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / diethyl ether; acetonitrile / 12 h / 20 °C

2.1: boron trioxide / N,N-dimethyl-formamide / 0.5 h / 75 °C / Inert atmosphere

2.2: 0.08 h / Inert atmosphere

With boron trioxide; chloro-trimethyl-silane; In diethyl ether; N,N-dimethyl-formamide; acetonitrile; 1.1: |Mannich Aminomethylation;
DOI:10.1002/ardp.201700005