(2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane

Base Information

Chemical Name:(2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane
CAS No.:209262-40-8
Molecular Formula:C₃₂H₂₉N₅O₆
Molecular Weight:579.612
Hs Code.:

Synonyms:(2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane

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Technology Process of (2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane

There total 6 articles about (2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66572-56-3
2-bromoisonicotinic acid

: 209262-40-8
(2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane

Guidance literature:: Multi-step reaction with 4 steps

1: DCC; HOBt / CH₂Cl₂ / 25 °C

2: NaBH₄; MeOH / tetrahydrofuran / Heating

3: CuI; K₂CO₃ / dimethylformamide / 120 °C

4: Et₃N / CH₂Cl₂ / 25 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Ullmann condensation;
DOI:10.1016/S0960-894X(03)00438-4

Reference yield:

: 108-24-7
acetic anhydride

: 209262-39-5
(2S)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}-3-(3,4-dimethoxyphenyl)-1-propanol

: 209262-40-8
(2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃;
DOI:10.1016/S0960-894X(03)00438-4

Reference yield:

: 129077-93-6
(S)-(+)-3,4-dimethoxyphenylalanine ethyl ester hydrochloride

: 209262-40-8
(2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane

Guidance literature:: Multi-step reaction with 4 steps

1: DCC; HOBt / CH₂Cl₂ / 25 °C

2: NaBH₄; MeOH / tetrahydrofuran / Heating

3: CuI; K₂CO₃ / dimethylformamide / 120 °C

4: Et₃N / CH₂Cl₂ / 25 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; potassium carbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Ullmann condensation;
DOI:10.1016/S0960-894X(03)00438-4