2-Bromopyridine-4-carboxylic acid

Base Information

• Chemical Name: 2-Bromopyridine-4-carboxylic acid
• CAS No.: 66572-56-3
• Molecular Formula: C6H4BrNO2
• Molecular Weight: 202.007
• Hs Code.: 29333990
• Mol file: 66572-56-3.mol

Synonyms:Isonicotinicacid, 2-bromo- (7CI);2-Bromo-4-pyridinecarboxylic acid;NSC 9462;2-Bromo-4-Pyridine Carboxylic Acid;

Chemical Property of 2-Bromopyridine-4-carboxylic acid

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 8.78E-09mmHg at 25°C
• Melting Point: 229-231 °C
• Boiling Point: 447.241 °C at 760 mmHg
• PKA: 2.98±0.10(Predicted)
• Flash Point: 224.3 °C
• PSA: 50.19000
• Density: 1.813 g/cm³
• LogP: 1.54230
• Storage Temp.: Keep Cold

Purity/Quality:

99% ^*data from raw suppliers

2-Bromoisonicotinic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Bromopyridine-4-carboxylic acid

There total 6 articles about 2-Bromopyridine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-Bromo-4-picoline (4926-28-7) → 2-bromoisonicotinic acid (66572-56-3)

Guidance literature:

With potassium dichromate; sulfuric acid; at 20 - 50 ℃; for 2h;

Reference yield: 82.0%

2-Bromo-4-picoline (4926-28-7) + chromium(VI) oxide (1333-82-0) → 2-bromoisonicotinic acid (66572-56-3)

Guidance literature:

In (2S)-N-methyl-1-phenylpropan-2-amine hydrate; sulfuric acid;

Reference yield: 46.0%

2-chloroisonicotinic acid, (6313-54-8) → 2-bromoisonicotinic acid (66572-56-3)

Guidance literature:

With hydrogen bromide; acetic acid; In water; for 28h; Reflux;

DOI:10.1142/S1088424615500169

upstream raw materials:

2-Bromo-4-picoline

2-Amino-4-methylpyridine

chromium(VI) oxide

2-chloroisonicotinic acid,

Downstream raw materials:

2-isobutoxy-isonicotinic acid

N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester

2-bromo-N-methyl-N-(methyloxy)-4-pyridinecarboxamide

2-phenylpyridine-4-carboxylic acid

Refernces

• 1、 Chattopadhyay, Buddhadeb,Das, Sandip Kumar,Khatua, Hillol,Roy, Satyajit. "Dual Reactivity of 1,2,3,4-Tetrazole: Manganese-Catalyzed Click Reaction and Denitrogenative Annulation". supporting information. p. 304 - 312. Retrieved 2020/10/29.
• 2、 Roy, Satyajit,Khatua, Hillol,Das, Sandip Kumar,Chattopadhyay, Buddhadeb. "Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation". supporting information. p. 11439 - 11443. Retrieved 2019/07/17.