4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid

Base Information

Chemical Name:4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid
CAS No.:1000068-13-2
Molecular Formula:C₂₅H₂₄N₄O₅
Molecular Weight:460.489
Hs Code.:

Synonyms:4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid

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Chemical Property of 4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid

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Technology Process of 4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid

There total 1 articles about 4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000068-09-6
4-[(6-chloropyrazin-2-yl)amino]-3-methoxybenzoic acid

: 213318-44-6
N-Boc-indole-2-boronic acid

: 1000068-13-2
4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid

Guidance literature:: With sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 100 ℃; for 5h;

Reference yield: 52.0%

: 1000068-13-2
4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid

: 147081-44-5
(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

: 4-{[6-(1H-indol-2-yl)pyrazin-2-yl]amino}-3-methoxy-N-[(3S)-pyrrolidin-3-yl]benzamide dihydrochloride

Guidance literature:: 4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid; (3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 54h;

With hydrogenchloride; In methanol; diethyl ether; for 3h;

Reference yield: 49.0%

: 1000068-13-2
4-({6-[1-(tert-butoxycarbonyl)-1H-indol-2-yl]pyrazin-2-yl}amino)-3-methoxybenzoic acid

: 70180-92-6
4-Amino-1,2-diethyl-pyrazolidine

: N-(1,2-diethylpyrazolidin-4-yl)-4-{[6-(1H-indol-2-yl)pyrazin-2-yl]amino}-3-methoxybenzamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 - 140 ℃; for 22h;