2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile

Base Information

Chemical Name:2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile
CAS No.:914954-60-2
Molecular Formula:C₁₉H₂₂ClN₃O
Molecular Weight:343.856
Hs Code.:

Synonyms:2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile

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Chemical Property of 2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile

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Technology Process of 2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile

There total 7 articles about 2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 796600-15-2
2-chloro-4-fluoro-3-methylbenzonitrile

: 914954-59-9
5-amino-4-methyl-2-pyridin-3-yl-pentan-2-ol

: 914954-60-2
2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile

Guidance literature:: With 1-methyl-pyrrolidin-2-one; at 120 ℃; for 2h; microwave reactor;

Reference yield:

: 59-67-6
nicotinic acid

: 914954-60-2
2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / acetonitrile / 2 h / 20 °C

2: tetrahydrofuran / 3 h / -78 - 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.5 h

4: sodium tetrahydroborate / methanol / 2 h / 20 °C

5: hydrogen / sulfided platinum on carbon (Pt-C(S)) / ethanol / 24 h / 20 °C / 5320.36 Torr

6: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C / microwave reactor

With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; hydrogen; benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sulfided platinum on carbon (Pt-C(S)); In tetrahydrofuran; methanol; ethanol; acetonitrile;

Reference yield:

: 914954-56-6
3-methyl-1-pyridin-3-yl-but-2-en-1-one

: 914954-60-2
2-chloro-4-(4-hydroxy-2,2-dimethyl-4-pyridin-3-yl-butylamino)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 0.5 h

2: sodium tetrahydroborate / methanol / 2 h / 20 °C

3: hydrogen / sulfided platinum on carbon (Pt-C(S)) / ethanol / 24 h / 20 °C / 5320.36 Torr

4: 1-methyl-pyrrolidin-2-one / 2 h / 120 °C / microwave reactor

With 1-methyl-pyrrolidin-2-one; sodium tetrahydroborate; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; sulfided platinum on carbon (Pt-C(S)); In methanol; ethanol;