(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid

Base Information

Chemical Name:(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid
CAS No.:1399358-40-7
Molecular Formula:C₁₆H₂₁N₃O₆
Molecular Weight:351.359
Hs Code.:

Synonyms:(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid

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Chemical Property of (2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid

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Technology Process of (2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid

There total 3 articles about (2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1399358-39-4
(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester

: 1399358-40-7
(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid

Guidance literature:: With ammonium hydroxide; In water; at 20 ℃; for 18h;
DOI:10.1002/anie.201202043

Reference yield:

: 910548-22-0
(2S,3R)-3-methylglutamic acid hydrochloride

: 1399358-40-7
(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 0.17 h / -20 °C / Inert atmosphere

1.2: 0.5 h / 5 °C / Inert atmosphere

1.3: 18 h / Inert atmosphere; Cooling

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0.58 h / 1 - 20 °C

3.1: ammonium hydroxide / water / 18 h / 20 °C

With ammonium hydroxide; thionyl chloride; sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1002/anie.201202043

Reference yield:

: 2899-60-7
Cbz-Gly-ONSuc

: 1399358-44-1
(2S,3R)-3-methyl-5-methoxy glutamic acid hydrochloride

: 1399358-40-7
(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-4-carbamoyl-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 0.58 h / 1 - 20 °C

2: ammonium hydroxide / water / 18 h / 20 °C

With ammonium hydroxide; sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1002/anie.201202043