(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester

Base Information

Chemical Name:(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester
CAS No.:1399358-39-4
Molecular Formula:C₁₇H₂₂N₂O₇
Molecular Weight:366.371
Hs Code.:

Synonyms:(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester

Chemical Property:

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Technology Process of (2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester

There total 2 articles about (2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2899-60-7
Cbz-Gly-ONSuc

: 1399358-44-1
(2S,3R)-3-methyl-5-methoxy glutamic acid hydrochloride

: 1399358-39-4
(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 1 - 20 ℃; for 0.583333h;
DOI:10.1002/anie.201202043

Reference yield:

: 910548-22-0
(2S,3R)-3-methylglutamic acid hydrochloride

: 1399358-39-4
(2S,3R)-2-(2-(benzyloxycarbonylamino)acetylamino)-3-methyl-pentanedioic acid 5-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 0.17 h / -20 °C / Inert atmosphere

1.2: 0.5 h / 5 °C / Inert atmosphere

1.3: 18 h / Inert atmosphere; Cooling

2.1: sodium hydrogencarbonate / 1,4-dioxane; water / 0.58 h / 1 - 20 °C

With thionyl chloride; sodium hydrogencarbonate; In 1,4-dioxane; water;
DOI:10.1002/anie.201202043