methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

Base Information

Chemical Name:methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate
CAS No.:1351238-81-7
Molecular Formula:C₁₆H₁₄N₄O₃S
Molecular Weight:342.378
Hs Code.:

Synonyms:methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

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Chemical Property of methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

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Technology Process of methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

There total 3 articles about methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 56881-31-3
7-aminothieno[2,3-b]pyrazine-6-carboxylic acid

: 1351238-81-7
methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 48h;

Reference yield:

: 56881-21-1
ethyl 7-aminothieno[2,3-b]-pyrazine-6-carboxylate

: 1351238-81-7
methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 70 °C

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 48 h / 80 °C

With water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 55557-52-3
2-chloro-3-cyanopyrazine

: 1351238-81-7
methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / ethanol / 4.5 h / Reflux

2: potassium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 70 °C

3: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 48 h / 80 °C

With water; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;