7-Aminothieno[2,3-b]pyrazine-6-carboxylic acid

Base Information

• Chemical Name: 7-Aminothieno[2,3-b]pyrazine-6-carboxylic acid
• CAS No.: 56881-31-3
• Molecular Formula: C7H5N3O2S
• Molecular Weight: 195.202
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50481284
• Wikidata: Q82316611

Synonyms:7-Aminothieno[2,3-b]pyrazine-6-carboxylic acid;56881-31-3;Diethylazelate;SCHEMBL1698022;DTXSID50481284;UJUCBOIXAMPUQL-UHFFFAOYSA-N;BDBM105185;MFCD08271964;AKOS006345480;AS-44089;CS-0234730;FT-0730538;EN300-146468;7-aminothieno[2,3-b]pyrazine-6-carboxylic acid (MB41-1);7-aminothieno[2,3-b]pyrazine-6-carboxylic acid, AldrichCPR

Chemical Property of 7-Aminothieno[2,3-b]pyrazine-6-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 250 °C
• Refractive Index: 1.822
• Boiling Point: 464.971 °C at 760 mmHg
• Flash Point: 235.006 °C
• PSA: 117.34000
• Density: 1.707g/cm³
• LogP: 1.55290
• Storage Temp.: 2-8°C
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 195.01024758
• Heavy Atom Count: 13
• Complexity: 226

Purity/Quality:

99% HPLC ^*data from raw suppliers

7-Aminothieno[2,3-b]pyrazine-6-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CN=C2C(=N1)C(=C(S2)C(=O)O)N
• Uses: 7-aminothieno[2,3-b]pyrazine-6-carboxylic acid is used as a reactant in the preparation of thieno[2,3-b]pyrazine derivatives as B-Raf inhibitors.

Technology Process of 7-Aminothieno[2,3-b]pyrazine-6-carboxylic acid

There total 2 articles about 7-Aminothieno[2,3-b]pyrazine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 7-aminothieno[2,3-b]-pyrazine-6-carboxylate (56881-21-1) → 7-aminothieno[2,3-b]pyrazine-6-carboxylic acid (56881-31-3)

Guidance literature:

With potassium hydroxide; In ethanol; Heating;

Reference yield:

2-chloro-3-cyanopyrazine (55557-52-3) → 7-aminothieno[2,3-b]pyrazine-6-carboxylic acid (56881-31-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / ethanol / Heating

2: KOH / ethanol / Heating

With potassium hydroxide; sodium carbonate; In ethanol;

Reference yield: 18.0%

N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide (30069-31-9) + 7-aminothieno[2,3-b]pyrazine-6-carboxylic acid (56881-31-3) → 7-amino-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)thieno[2,3-b]pyrazine-6-carboxamide (1351237-70-1)

Guidance literature:

7-aminothieno[2,3-b]pyrazine-6-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide; In N,N-dimethyl-formamide; at 80 ℃;

upstream raw materials:

ethyl 7-aminothieno[2,3-b]-pyrazine-6-carboxylate

2-chloro-3-cyanopyrazine

Downstream raw materials:

thieno[2,3-b]pyrazin-7-amine

methyl 3-(7-aminothieno[2,3-b]pyrazine-6-carboxamido)-4-methylbenzoate

7-amino-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)thieno[2,3-b]pyrazine-6-carboxamide

7-amino-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide

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