5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid

Base Information

Chemical Name:5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid
CAS No.:1544664-03-0
Molecular Formula:C₁₉H₁₆F₆O₃
Molecular Weight:406.325
Hs Code.:

Synonyms:5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid

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Chemical Property of 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid

Chemical Property:

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Technology Process of 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid

There total 8 articles about 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1544664-00-7
methyl 5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoate

: 1544664-03-0
5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 70 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.1c00211

Reference yield:

: 1544665-15-7
2-bromo-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene

: 1544664-03-0
5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 20 °C

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 85 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 4 h / 100 °C / 11400.8 Torr / Autoclave

4: sodium hydroxide; methanol / 2 h / 70 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; copper(l) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1544663-98-0
6-bromo-1-(trifluoromethyl)-2-((cis-4-(trifluoromethyl)cyclohexyl)oxy)naphthalene

: 1544664-03-0
5-(trifluoromethyl)-6-((cis-4-(trifluoromethyl)cyclohexyl)oxy)-2-naphthoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 4 h / 100 °C / 11400.8 Torr / Autoclave

2: sodium hydroxide; methanol / 2 h / 70 °C

With methanol; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; sodium hydroxide;