3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile
CAS No.:1093988-12-5
Molecular Formula:C₂₃H₁₂Cl₂F₃N₃O₃
Molecular Weight:506.268
Hs Code.:

Synonyms:3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

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Chemical Property of 3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

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Technology Process of 3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

There total 10 articles about 3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-21-1
zinc(II) cyanide

: 1093988-13-6
2-({3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}methyl)-5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazole

: 1093988-12-5
3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 135 ℃; for 0.166667h; Microwave;

Reference yield:

: 33863-76-2
1-bromo-3-chloro-5-fluorobenzene

: 1093988-12-5
3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: N,N-dimethyl-formamide / 20 °C

2.1: boron tribromide / dichloromethane / 20 °C

2.2: 20 °C

3.1: sodium t-butanolate / tetrahydrofuran / 0.25 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

5.2: 0 °C

6.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

7.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

8.1: hydrazine / ethanol / 8 h / Reflux

9.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.75 h / 20 °C

9.2: 20 °C

10.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 135 °C / Microwave

With tert.-butylnitrite; sodium dithionite; boron tribromide; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; copper dichloride; sodium t-butanolate; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 874974-99-9
2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

: 1093988-12-5
3-chloro-5-({6-chloro-3-[(5-{3-[(difluoromethyl)oxy]phenyl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.75 h / 20 °C

1.2: 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.17 h / 135 °C / Microwave

With N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;