2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

Base Information

Chemical Name:2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide
CAS No.:874974-99-9
Molecular Formula:C₁₄H₁₀BrCl₂FN₂O₂
Molecular Weight:408.054
Hs Code.:

Synonyms:2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

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Chemical Property of 2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

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Technology Process of 2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

There total 8 articles about 2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 874974-98-8
[4-chloro-3-(3-bromo-5-chloro-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

: 874974-99-9
2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

Guidance literature:: With hydrazine; In ethanol; for 23h; Reflux;

Reference yield:

: 33863-76-2
1-bromo-3-chloro-5-fluorobenzene

: 874974-99-9
2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide / 20 °C

2.1: boron tribromide / dichloromethane / 20 °C

2.2: 20 °C

3.1: sodium t-butanolate / tetrahydrofuran / 0.25 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

5.2: 0 °C

6.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

7.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

8.1: hydrazine / ethanol / 8 h / Reflux

With tert.-butylnitrite; sodium dithionite; boron tribromide; sodium hydride; trifluoroacetic acid; copper dichloride; sodium t-butanolate; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 56962-04-0
3-bromo-5-chlorophenol

: 874974-99-9
2-{3-[(3-bromo-5-chlorophenyl)oxy]-4-chloro-2-fluorophenyl}acetohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium t-butanolate / tetrahydrofuran / 0.25 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

2.2: 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 0.75 h / 0 - 60 °C

3.2: 0 °C

4.1: sodium dithionite / tetrahydrofuran; water / 1 h / 20 °C

5.1: tert.-butylnitrite; copper dichloride / acetonitrile / 0.25 h / 50 °C

6.1: hydrazine / ethanol / 8 h / Reflux

With tert.-butylnitrite; sodium dithionite; sodium hydride; trifluoroacetic acid; copper dichloride; sodium t-butanolate; hydrazine; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile; mineral oil;