1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

Base Information

Chemical Name:1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione
CAS No.:1408245-05-5
Molecular Formula:C₂₂H₂₀F₃N₅O₂
Molecular Weight:443.428
Hs Code.:

Synonyms:1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

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Chemical Property of 1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

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Technology Process of 1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

There total 11 articles about 1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1295301-38-0
3-methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)imidazolidine-2,4-dione

: 1407167-77-4
1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl trifluoromethanesulfonate

: 1408245-05-5
1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 1h;

Reference yield:

: 96-96-8
4-methoxy-2-nitroaniline

: 1408245-05-5
1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 10 steps

1.1: acetic acid / dichloromethane / 1.08 h / 10 °C

1.2: 18 h / 10 - 20 °C

2.1: hydrogen / 3percent Pt/0.6percentVG/C, deGussa / ethanol / 2.5 h / 10 °C / 2068.65 Torr / Inert atmosphere

3.1: methanesulfonic acid; isopentyl nitrite / ethanol / 0.25 h

4.1: boron tribromide / dichloromethane / 3 h / 0 - 20 °C

4.2: 15 h

4.3: pH < 5

5.1: N-iodo-succinimide / acetic acid / 0.25 h

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 50 °C

7.1: copper(l) iodide / N,N-dimethyl-formamide / 1.5 h / 100 °C

8.1: hydrogen / 10 wt% Pd(OH)2 on carbon / ethyl acetate; methanol / 1.5 h / 760.05 Torr / Inert atmosphere

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 0 °C

10.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 90 °C

With potassium phosphate; N-iodo-succinimide; copper(l) iodide; methanesulfonic acid; hydrogen; boron tribromide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; isopentyl nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 138500-85-3
4-bromomethylphenylboronic acid pinacol ester

: 1408245-05-5
1-{4-[1-(cyclopropylmethyl)-4-(trifluoromethyl)-1H-benzotriazol-5-yl]benzyl}-3-methylimidazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 45 °C

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 90 °C

With potassium phosphate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide;