138500-85-3Relevant articles and documents
Synthesis and Automated Labeling of [18F]Darapladib, a Lp-PLA2 Ligand, as Potential PET Imaging Tool of Atherosclerosis
Guibbal, Florian,Meneyrol, Vincent,Ait-Arsa, Imade,Diotel, Nicolas,Patché, Jessica,Veeren, Bryan,Bénard, Sébastien,Gimié, Fanny,Yong-Sang, Jennyfer,Khantalin, Ilya,Veerapen, Reuben,Jestin, Emmanuelle,Meilhac, Olivier
, p. 743 - 748 (2019)
Atherosclerosis and its associated clinical complications are major health issues in industrialized countries. Lipoprotein-associated phospholipase A2 (Lp-PLA2) was demonstrated to play an important role in atherogenesis and to be a
A General Strategy Toward Highly Fluorogenic Bioprobes Emitting across the Visible Spectrum
Chen, Haoliang,He, Xiujing,Su, Meihui,Zhai, Wenhao,Zhang, Hao,Li, Changhua
, p. 10157 - 10163 (2017)
A general approach toward highly fluorogenic probes across the visible spectrum for various analytes offers significant potential for engineering a wide range of bioprobes with diverse sensing and imaging functions. Here we show a facile and general strategy that involves introducing a new fluorogenic mechanism in boron dipyrromethene (BODIPY) dyes, based on the principle of stimuli-triggered dramatic reduction in the electron-withdrawing capabilities of the meso-substituents of BODIPYs. The fluorogenic mechanism has been demonstrated to be applicable in various BODIPYs with emission maxima ranging from green to far red (509, 585, and 660 nm), and the synthetic strategy allows access to a panel of highly fluorogenic bioprobes for various biomolecules and enzymes (H2O2, H2S, and protease) via introducing specific triggering motifs. The potency of the general design strategy is exemplified by its application to develop a mitochondria-targeting far-red probe capable of imaging of endogenous H2O2 in living cells.
A Two-Photon Ratiometric Sensing Platform Based on Solid-State Luminescent Benzocoumarin: Application to Prolonged Bioimaging of Hydrogen Peroxide
Rim Kim, Hye,Sarkar, Sourav,Han Ahn, Kyo
, (2022/01/22)
Fluorescent probes provide essential tools for studying biological systems. For the prolonged imaging of cellular analytes, the fast clearance of small-molecular probes and products is a matter of concern in the quantitative analysis. Activatable probes that produce insoluble products inside cells can be used for prolonged imaging, but those with ratiometric imaging capability are rare. We disclose a novel sensing platform that is capable of prolonged imaging, in addition to ratiometric signaling for reliable quantitative analysis. Specifically, 3-(pyridin-4-yl)-8-(pyrrolidin-1-yl)-2H-benzo[g]chromen-2-one and its pyridinium salt as a product/probe couple constitute the ratiometric sensing platform. As the former dye produces highly emissive insoluble nanoaggregates inside cells, a fluorescent probe in the latter form enables prolonged imaging of the target analyte in cells as well as in tissue by two-photon microscopy.
DRUG AND GENE THERAPY TO TREAT HIGH MYOPIA AND OTHER OCULAR DISORDERS WITH ENLARGED EYE GLOBES
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, (2021/12/29)
This invention relates to a treatment of various eye conditions relating to eye enlargement. The conditions can be treated by inhibiting an upstream protein within the said biological pathway or by increasing the expression of a downstream receptor within
Camptothecin derivative and applications thereof
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Paragraph 0060-0063, (2020/05/01)
The invention provides a camptothecin derivative and applications in preparation of antitumor drugs, wherein the camptothecin derivative has the following general formula (I). According to the invention, the MTT experiment results show that the camptothecin derivative has cytotoxicity only under ROS conditions, and has low cytotoxicity in a ROS-free culture solution; and based on high ROS concentration in tumor tissue, the anti-tumor medicine prepared from the camptothecin derivative has the advantage of low toxicity.