Technology Process of methyl (2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)acetate
There total 4 articles about methyl (2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
9-phenyl-1,3,4,5-tetrahydro-2H-1-benzoazepin-2-one;
With
sodium hydride;
In
N,N-dimethyl-formamide;
Cooling;
bromoacetic acid methyl ester;
In
N,N-dimethyl-formamide;
Cooling;
DOI:10.1021/jo2008725
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 1.5 h / Reflux
2.1: polyphosphoric acid / 1 h / 95 °C
3.1: tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; XPhos / N,N-dimethyl acetamide; water / 50 h / 100 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / Cooling
4.2: Cooling
With
tris-(dibenzylideneacetone)dipalladium(0); hydroxylamine hydrochloride; sodium acetate; sodium hydride; potassium carbonate; XPhos;
In
ethanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
2.1: Beckmann rearrangement / 3.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo2008725
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: polyphosphoric acid / 1 h / 95 °C
2.1: tris-(dibenzylideneacetone)dipalladium(0); potassium carbonate; XPhos / N,N-dimethyl acetamide; water / 50 h / 100 °C / Inert atmosphere
3.1: sodium hydride / N,N-dimethyl-formamide / Cooling
3.2: Cooling
With
tris-(dibenzylideneacetone)dipalladium(0); sodium hydride; potassium carbonate; XPhos;
In
N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;
1.1: Beckmann rearrangement / 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jo2008725
