N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide

Base Information

• Chemical Name: N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide
• CAS No.: 1374977-64-6
• Molecular Formula: C₂₆H₂₂F₄N₂O₂
• Molecular Weight: 470.466
• Mol file: 1374977-64-6.mol

Synonyms:

Chemical Property of N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide

There total 17 articles about N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

N-(4-fluoro-2-trifluoromethylphenyl)-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-60-2,1375091-87-4,1375091-90-9) + methyl iodide (74-88-4) → N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-64-6,1375091-93-2,1375091-96-5)

Guidance literature:

N-(4-fluoro-2-trifluoromethylphenyl)-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1002/chem.201103264

Reference yield:

N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-64-6,1375091-93-2,1375091-96-5) → N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-64-6,1375091-93-2,1375091-96-5) + N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-64-6,1375091-93-2,1375091-96-5)

Guidance literature:

With CHIRALPAK IA; In hexane; isopropyl alcohol; at 25 ℃; Resolution of racemate;

DOI:10.1002/chem.201103264

Reference yield:

N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-64-6,1375091-93-2,1375091-96-5) → N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-64-6,1375091-93-2,1375091-96-5) + N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide (1374977-64-6,1375091-93-2,1375091-96-5)

Guidance literature:

With CHIRALPAK IA; In hexane; isopropyl alcohol; at 25 ℃; Resolution of racemate;

DOI:10.1002/chem.201103264

upstream raw materials:

9-phenyl-1,3,4,5-tetrahydro-2H-1-benzoazepin-2-one

methyl (2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)acetate

N-(4-fluoro-2-trifluoromethylphenyl)-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide

methyl iodide

Downstream raw materials:

N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide

N-(4-fluoro-2-trifluoromethylphenyl)-N-methyl-2-(2-oxo-9-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetamide