ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate

Base Information

Chemical Name:ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate
CAS No.:159589-07-8
Molecular Formula:C₂₀H₂₃N₃O₃
Molecular Weight:353.421
Hs Code.:

Synonyms:ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate

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Technology Process of ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate

There total 4 articles about ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 159589-06-7
[5-(4-nitro-benzoyl)-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl]-acetic acid ethyl ester

: 159589-07-8
ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; under 760 Torr; Ambient temperature;
DOI:10.1248/cpb.46.1566

Reference yield:

: 6516-89-8
2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 159589-07-8
ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 51 percent / K₂CO₃ / dimethylformamide / 18 h / 100 °C

3: 98 percent / H₂ / 10 percent Pd/C / acetic acid / 760 Torr / Ambient temperature

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1566

Reference yield:

: 122-04-3
4-nitro-benzoyl chloride

: 159589-07-8
ethyl <5-(4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-1-yl>acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N / CH₂Cl₂ / 0.5 h / 0 - 5 °C

2: 51 percent / K₂CO₃ / dimethylformamide / 18 h / 100 °C

3: 98 percent / H₂ / 10 percent Pd/C / acetic acid / 760 Torr / Ambient temperature

With hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1566