5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide

Base Information

Chemical Name:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide
CAS No.:1202921-33-2
Molecular Formula:C₂₆H₁₉ClF₃N₃O₆
Molecular Weight:561.902
Hs Code.:

Synonyms:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide

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Chemical Property of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide

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Technology Process of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide

There total 5 articles about 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 747413-04-3
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethyl ester

: 1202921-33-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: water; lithium hydroxide / methanol / 24 h / 50 - 60 °C

2: thionyl chloride / 4 h / 80 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

With thionyl chloride; water; nitric acid; acetic anhydride; triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm201155e

Reference yield:

: 1202921-31-0
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

: 1202921-33-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide

Guidance literature:: With nitric acid; acetic anhydride; at 0 - 10 ℃; for 70h; chemoselective reaction; Inert atmosphere;
DOI:10.1021/jm201155e

Reference yield:

: C₂₄H₁₇Cl₂NO₄

: 1202921-33-2
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)-4-nitroisoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

2: nitric acid; acetic anhydride / 70 h / 0 - 10 °C / Inert atmosphere

With nitric acid; acetic anhydride; triethylamine; In dichloromethane;
DOI:10.1021/jm201155e