5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

Base Information

Chemical Name:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide
CAS No.:1202921-31-0
Molecular Formula:C₂₆H₂₀ClF₃N₂O₄
Molecular Weight:516.904
Hs Code.:

Synonyms:5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

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Chemical Property of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

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Technology Process of 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

There total 4 articles about 5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202921-29-6
5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid

: 373-88-6
2,2,2-trifluroethylamine hydrochloride

: 1202921-31-0
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

Guidance literature:: 5-[2,4-bis(benzyloxy)-5-chlorophenyl]isoxazole-3-carboxylic acid; With thionyl chloride; In toluene; at 110 ℃; for 5h;

2,2,2-trifluroethylamine hydrochloride; With triethylamine; In dichloromethane; toluene; at 20 ℃;

Reference yield:

: 753-90-2
trifluoroethylamine

: C₂₄H₁₇Cl₂NO₄

: 1202921-31-0
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1021/jm201155e

Reference yield:

: 747413-04-3
5-(2,4-bis(benzyloxy)-5-chlorophenyl)isoxazole-3-carboxylic acid ethyl ester

: 1202921-31-0
5-[2,4-bis(benzyloxy)-5-chlorophenyl]-N-(2,2,2-trifluoroethyl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / methanol / 24 h / 50 - 60 °C

2: thionyl chloride / 4 h / 80 °C / Inert atmosphere

3: triethylamine / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; water; triethylamine; lithium hydroxide; In methanol; dichloromethane;
DOI:10.1021/jm201155e