N¹,N²-bis(benzyloxycarbonyl)-N¹-(5-[(methanesulfonyl)oxy]pentyl)guanidine

Base Information

• Chemical Name: N¹,N²-bis(benzyloxycarbonyl)-N¹-(5-[(methanesulfonyl)oxy]pentyl)guanidine
• CAS No.: 503609-48-1
• Molecular Formula: C₂₃H₂₉N₃O₇S
• Molecular Weight: 491.565
• Mol file: 503609-48-1.mol

Synonyms:N¹,N²-bis(benzyloxycarbonyl)-N¹-(5-[(methanesulfonyl)oxy]pentyl)guanidine

Chemical Property of N¹,N²-bis(benzyloxycarbonyl)-N¹-(5-[(methanesulfonyl)oxy]pentyl)guanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹,N²-bis(benzyloxycarbonyl)-N¹-(5-[(methanesulfonyl)oxy]pentyl)guanidine

There total 1 articles about N¹,N²-bis(benzyloxycarbonyl)-N¹-(5-[(methanesulfonyl)oxy]pentyl)guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanesulfonyl chloride (124-63-0) + 5-amino>methyl>-N-<(phenylmethoxy)carbonyl>amino>pentan-1-ol (150252-73-6) → N1,N2-bis(benzyloxycarbonyl)-N1-(5-[(methanesulfonyl)oxy]pentyl)guanidine (503609-48-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

DOI:10.1021/ol034042e

Reference yield: 78.0%

N1,N2-bis(benzyloxycarbonyl)-N1-(5-[(methanesulfonyl)oxy]pentyl)guanidine (503609-48-1) → N1,N2-bis(benzyloxycarbonyl)-N1-(5-iodopentyl)guanidine (503609-49-2)

Guidance literature:

With sodium hydrogencarbonate; sodium iodide; sodium sulfite; In acetone; for 3h; Heating;

DOI:10.1021/ol034042e

Reference yield:

N1,N2-bis(benzyloxycarbonyl)-N1-(5-[(methanesulfonyl)oxy]pentyl)guanidine (503609-48-1) → 5-[[imino[[benzyloxycarbonyl]amino]methyl][benzyloxycarbonyl]amino]pentyl-2,3,4,6,7,8-hexahydro-pyrrolo[1,2-a]pyrimidinium iodide

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / NaHCO₃; Na₂SO₃; NaI / acetone / 3 h / Heating

2: 87 percent / dimethylsulfoxide-d6 / 24 h

With sodium hydrogencarbonate; sodium iodide; sodium sulfite; In dimethylsulfoxide-d6; acetone;

DOI:10.1021/ol034042e

upstream raw materials:

methanesulfonyl chloride

5-amino>methyl>-N-<(phenylmethoxy)carbonyl>amino>pentan-1-ol

Downstream raw materials:

N¹,N²-bis(benzyloxycarbonyl)-N¹-(5-iodopentyl)guanidine