3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Base Information

Chemical Name:3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide
CAS No.:1282520-92-6
Molecular Formula:C₁₅H₁₈N₂O₄S
Molecular Weight:322.385
Hs Code.:

Synonyms:3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

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Chemical Property of 3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

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Technology Process of 3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

There total 3 articles about 3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.5%

: 1282520-91-5
5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-isophthalic acid methyl ester

: 1282520-92-6
3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Guidance literature:: With lithium borohydride; ethanol; In tetrahydrofuran; at 0 - 20 ℃; for 12h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-92-6
3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: thionyl chloride / 2 h / 100 °C

3.2: 12 h / 20 °C

4.1: lithium borohydride; ethanol / tetrahydrofuran / 12 h / 0 - 20 °C

With methanol; lithium borohydride; thionyl chloride; ethanol; di-isopropyl azodicarboxylate; triphenylphosphine; potassium hydroxide; In tetrahydrofuran;

Reference yield:

: 1282520-89-1
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester

: 1282520-92-6
3-hydroxymethyl-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; methanol / 12 h / 100 °C

2.1: thionyl chloride / 2 h / 100 °C

2.2: 12 h / 20 °C

3.1: lithium borohydride; ethanol / tetrahydrofuran / 12 h / 0 - 20 °C

With methanol; lithium borohydride; thionyl chloride; ethanol; potassium hydroxide; In tetrahydrofuran;