3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Base Information

Chemical Name:3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide
CAS No.:1282520-14-2
Molecular Formula:C₂₂H₂₃FN₂O₃S
Molecular Weight:414.501
Hs Code.:

Synonyms:3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

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Chemical Property of 3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

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Technology Process of 3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

There total 8 articles about 3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1282519-29-2
3-[trans-2-(2-fluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

: 1282520-14-2
3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 12h;

Reference yield:

: 13036-02-7
Dimethyl 5-hydroxyisophthalate

: 1282520-14-2
3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 12 h / 0 - 20 °C

2.1: potassium hydroxide; methanol / 12 h / 100 °C

3.1: thionyl chloride / 2 h / 100 °C

3.2: 12 h / 20 °C

4.1: lithium borohydride; ethanol / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: tribromide phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

6.1: 3 h / 160 °C

7.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 20 h / 0 - 20 °C

8.1: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C

With methanol; lithium borohydride; thionyl chloride; ethanol; di-isopropyl azodicarboxylate; tribromide phosphate; hydrogen; triphenylphosphine; potassium hydroxide; 18-crown-6 ether; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1282520-89-1
5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester

: 1282520-14-2
3-[2-(2-fluorophenyl)ethyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(thiazol-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; methanol / 12 h / 100 °C

2.1: thionyl chloride / 2 h / 100 °C

2.2: 12 h / 20 °C

3.1: lithium borohydride; ethanol / tetrahydrofuran / 12 h / 0 - 20 °C

4.1: tribromo phosphate / tetrahydrofuran / 12 h / 0 - 20 °C

5.1: 3 h / 160 °C

6.1: potassium hydroxide / 18-crown-6 ether / dichloromethane / 20 h / 0 - 20 °C

7.1: hydrogen / palladium on activated charcoal / ethyl acetate / 12 h / 20 °C

With methanol; lithium borohydride; thionyl chloride; ethanol; tribromo phosphate; hydrogen; potassium hydroxide; 18-crown-6 ether; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;