α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

Base Information

Chemical Name:α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate
CAS No.:79648-88-7
Molecular Formula:C₂₅H₃₂N₈O₅
Molecular Weight:524.58
Hs Code.:

α-tert-butyl γ-methyl N'-<4-<N-<(2,4-diamino-6-pteridinyl)methyl>-N-methylamino>benzoyl>-L-glutamate

Synonyms:α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

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Chemical Property of α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

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Technology Process of α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

There total 11 articles about α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59368-16-0
6-bromomethyl-pteridine-2,4-diamine

: 472960-79-5
2-(4-methylamino-benzoylamino)-pentanedioic acid 1-tert-butyl ester 5-methyl ester

: 79648-88-7
α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

Guidance literature:: With triethylamine; In N,N-dimethyl acetamide; at 50 ℃;
DOI:10.1016/j.bmcl.2004.01.106

Reference yield:

: 79640-72-5
L-glutamic acid 1-tert-butyl ester 5-methyl ester

: 19741-14-1
4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

: 79648-88-7
α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

Guidance literature:: With diethyl cyanophosphonate; triethylamine; Yield given. Multistep reaction; 1.) DMF, 80 deg C, 2 min, 2.) DMF, 80 deg C, 2 h;
DOI:10.1021/jm00144a016

Reference yield:

: 79640-72-5
L-glutamic acid 1-tert-butyl ester 5-methyl ester

: 79648-88-7
α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: WSCI*HCl; HOBt / dimethylformamide

2: H₂ / Pd(OH)2/C / methanol

3: Et₃N / N,N-dimethyl-acetamide / 50 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium dihydroxide; In methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2004.01.106