(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid

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Chemical Name:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid
CAS No.:121788-84-9
Molecular Formula:C₂₂H₂₃F₃N₁₀O₄
Molecular Weight:548.484
Hs Code.:

Synonyms:(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid

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Chemical Property of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid

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Technology Process of (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid

There total 5 articles about (S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59-05-2
N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid

: 121788-84-9
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / sodium sulfate / tetrafluoroboric acid etherate / 18 h / Ambient temperature

2: 91 percent / N₂H₄*H₂O / methanol / 48 h / Ambient temperature

3: dimethylformamide; tetrahydrofuran / 18 h / 25 °C

With hydrazine hydrate; sodium sulfate; tetrafluoroboric acid diethyl ether; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00131a003

Reference yield:

: 10541-83-0,937737-33-2
N-methyl-p-aminobenzoic acid

: 121788-84-9
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) dibromotriphenylphosphorane, 2.) N-ethyldiisopropylamine / 1.) DMA, room temperature, 24 h, 2.) room temperature, 48 h

2: 1.) diethyl cyanophosphonate, N-ethyldiisopropylamine, 2.) N-ethyldiisopropylamine / 1.) DMF, room temperature, 4 h, 2.) room temperature, 72 h

3: 91 percent / N₂H₄*H₂O / methanol / 48 h / Ambient temperature

4: dimethylformamide; tetrahydrofuran / 18 h / 25 °C

With diethyl cyanophosphonate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; dibromotriphenylphosphorane; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00131a003

Reference yield:

: 67022-39-3
γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

: 121788-84-9
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-[2,2,2-trifluoro-eth-(E)-ylidene-hydrazinocarbonyl]-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / N₂H₄*H₂O / methanol / 48 h / Ambient temperature

2: dimethylformamide; tetrahydrofuran / 18 h / 25 °C

With hydrazine hydrate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00131a003