[(3β)-Cholesta-5,24-dien-3-yloxy](1,1-diMethylethyl)diMethylsilane

Base Information

Chemical Name:[(3β)-Cholesta-5,24-dien-3-yloxy](1,1-diMethylethyl)diMethylsilane
CAS No.:220150-72-1
Molecular Formula:C₃₃H₅₈OSi
Molecular Weight:498.908
Hs Code.:
Mol file:220150-72-1.mol

Synonyms:tert-Butyl-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hex-4-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-dimethyl-silane

Suppliers and Price of [(3β)-Cholesta-5,24-dien-3-yloxy](1,1-diMethylethyl)diMethylsilane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
[(3β)-Cholesta-5,24-dien-3-yloxy](1,1-dimethylethyl)dimethylsilane
5mg
$ 660.00

Medical Isotopes, Inc.
[(3β)-Cholesta-5,24-dien-3-yloxy](1,1-dimethylethyl)dimethylsilane
1 mg
$ 650.00

Total 1 raw suppliers

Chemical Property of [(3β)-Cholesta-5,24-dien-3-yloxy](1,1-diMethylethyl)diMethylsilane

Chemical Property:

Boiling Point:521.4±29.0 °C(Predicted)
Density:0.94±0.1 g/cm3(Predicted)
Solubility.:Chloroform, DCM, Ethyl Acetate

Purity/Quality:: [(3β)-Cholesta-5,24-dien-3-yloxy](1,1-dimethylethyl)dimethylsilane ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses [(3β)-cholesta-5,24-dien-3-yloxy](1,1-dimethylethyl)dimethylsilane is an protected intermediate in the synthesis of Desmosterol (D296860), a metabolite of Cholesterol (C432501).

Technology Process of [(3β)-Cholesta-5,24-dien-3-yloxy](1,1-diMethylethyl)diMethylsilane

There total 6 articles about [(3β)-Cholesta-5,24-dien-3-yloxy](1,1-diMethylethyl)diMethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 24470-78-8
isopropyltriphenylphosphonium iodide

: 84529-74-8
(20R)-3β-(tert-butyldimethylsilyloxy)-24-oxo-25,26,27-trisnorcholest-5-ene

: 220150-72-1
tert-Butyl-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hex-4-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-dimethyl-silane

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at -20 ℃;
DOI:10.1016/S0040-4039(98)02181-9

Reference yield:

: 140659-51-4,96354-26-6
(2β,20S)-3-<(tert-butyldimethylsilyl)oxy>pregn-5-ene-20-carboxaldehyde

: 220150-72-1
tert-Butyl-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hex-4-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / LiCl, DBU / CH₂Cl₂; acetonitrile

2: 93 percent / Mg⁽⁰⁾ / methanol; benzene / 25 °C

3: 72 percent / DIBAL-H / toluene / -78 °C

4: 85 percent / KHMDS / tetrahydrofuran / -20 °C

With potassium hexamethylsilazane; diisobutylaluminium hydride; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(98)02181-9

Reference yield:

: 69454-88-2
3β-((tert-butyldimethylsilyl)oxy)-22-hydroxy-23,24-bisn-orchol-5-en

: 220150-72-1
tert-Butyl-[(3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hex-4-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: Swern oxidn. / -40 °C

2: 85 percent / LiCl, DBU / CH₂Cl₂; acetonitrile

3: 93 percent / Mg⁽⁰⁾ / methanol; benzene / 25 °C

4: 72 percent / DIBAL-H / toluene / -78 °C

5: 85 percent / KHMDS / tetrahydrofuran / -20 °C

With Swern oxidn; potassium hexamethylsilazane; diisobutylaluminium hydride; magnesium; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(98)02181-9