(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

Base Information

Chemical Name:(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile
CAS No.:194737-50-3
Molecular Formula:C₂₄H₂₆N₂O₃
Molecular Weight:390.482
Hs Code.:

Synonyms:(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

Suppliers and Price of (R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

There total 8 articles about (R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5804-85-3
diethylaluminium cyanide

: 194737-49-0
(4R)-2-(E)-[2-(3-cyclopentyloxy-4-methoxyphenyl)ethenyl]-4-phenyl-4,5-dihydroxyoxazole

: 194737-50-3
(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

: (S)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

Guidance literature:: With molecular sieve; In dichloromethane; toluene; at 18 ℃; for 94h; Yield given. Yields of byproduct given;
DOI:10.1080/00397919708004171

Reference yield:

: 621-59-0
isovanillin

: 194737-50-3
(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 1.6 h / 100 °C

2: NaH / paraffin; toluene / 0.83 h / Ambient temperature

3: 2N NaOH / methanol / 15 h / Ambient temperature

4: SOCl₂ / toluene / 2.5 h / 95 °C

5: DMAP, Et₃N / CH₂Cl₂ / 22.5 h / Ambient temperature

6: 92 percent / POCl₃ / toluene / Ambient temperature

7: molecular sieves / toluene; CH₂Cl₂ / 94 h / 18 °C

With dmap; sodium hydroxide; thionyl chloride; molecular sieve; sodium hydride; potassium carbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; paraffin;
DOI:10.1080/00397919708004171

Reference yield:

: 137-43-9
Cyclopentyl bromide

: 194737-50-3
(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 1.6 h / 100 °C

2: NaH / paraffin; toluene / 0.83 h / Ambient temperature

3: 2N NaOH / methanol / 15 h / Ambient temperature

4: SOCl₂ / toluene / 2.5 h / 95 °C

5: DMAP, Et₃N / CH₂Cl₂ / 22.5 h / Ambient temperature

6: 92 percent / POCl₃ / toluene / Ambient temperature

7: molecular sieves / toluene; CH₂Cl₂ / 94 h / 18 °C

With dmap; sodium hydroxide; thionyl chloride; molecular sieve; sodium hydride; potassium carbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; paraffin;
DOI:10.1080/00397919708004171