(2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

Base Information

Chemical Name:(2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol
CAS No.:194737-52-5
Molecular Formula:C₂₄H₃₀N₂O₃
Molecular Weight:394.514
Hs Code.:

Synonyms:(2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

Chemical Property:

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Technology Process of (2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

There total 8 articles about (2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 194737-50-3
(R)-2-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-((R)-4-phenyl-4,5-dihydro-oxazol-2-yl)-propionitrile

: 194737-52-5
(2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

Guidance literature:: With sodium tetrahydroborate; nickel dichloride; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1080/00397919708004171

Reference yield:

: 621-59-0
isovanillin

: 194737-52-5
(2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 1.6 h / 100 °C

2: NaH / paraffin; toluene / 0.83 h / Ambient temperature

3: 2N NaOH / methanol / 15 h / Ambient temperature

4: SOCl₂ / toluene / 2.5 h / 95 °C

5: DMAP, Et₃N / CH₂Cl₂ / 22.5 h / Ambient temperature

6: 92 percent / POCl₃ / toluene / Ambient temperature

7: molecular sieves / toluene; CH₂Cl₂ / 94 h / 18 °C

8: 69 percent / NiCl₂*6H₂O, NaBH₄ / tetrahydrofuran / 1 h / Ambient temperature

With dmap; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; molecular sieve; sodium hydride; potassium carbonate; triethylamine; nickel dichloride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; paraffin;
DOI:10.1080/00397919708004171

Reference yield:

: 67387-76-2
3-cyclopentyloxy-4-methoxybenzylaldehyde

: 194737-52-5
(2R,4R)-2-[4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolin-2-yl]amino-2-phenylethanol

Guidance literature:: Multi-step reaction with 7 steps

1: NaH / paraffin; toluene / 0.83 h / Ambient temperature

2: 2N NaOH / methanol / 15 h / Ambient temperature

3: SOCl₂ / toluene / 2.5 h / 95 °C

4: DMAP, Et₃N / CH₂Cl₂ / 22.5 h / Ambient temperature

5: 92 percent / POCl₃ / toluene / Ambient temperature

6: molecular sieves / toluene; CH₂Cl₂ / 94 h / 18 °C

7: 69 percent / NiCl₂*6H₂O, NaBH₄ / tetrahydrofuran / 1 h / Ambient temperature

With dmap; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; molecular sieve; sodium hydride; triethylamine; nickel dichloride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; toluene; paraffin;
DOI:10.1080/00397919708004171