4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole

Base Information

• Chemical Name: 4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole
• CAS No.: 1190831-15-2
• Molecular Formula: C₂₅H₂₆N₂O₂S
• Molecular Weight: 418.56

Synonyms:4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole

Chemical Property of 4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole

Chemical Property:

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Technology Process of 4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole

There total 2 articles about 4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-toluenesulfonyl fluoride (455-16-3) + phenyllithium (591-51-5) + 3,4,4-trimethyl-5-phenyl-4H-pyrazole (30169-46-1) → 4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole (1190831-15-2)

Guidance literature:

phenyllithium; 3,4,4-trimethyl-5-phenyl-4H-pyrazole; In tetrahydrofuran; diethyl ether; cyclohexane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

p-toluenesulfonyl fluoride; In tetrahydrofuran; diethyl ether; cyclohexane; at 20 ℃; for 3h;

DOI:10.1515/HC.2008.14.6.449

Reference yield:

phenyllithium (591-51-5) + p-toluenesulfonyl chloride (98-59-9) + 3,4,4-trimethyl-5-phenyl-4H-pyrazole (30169-46-1) → 4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole (1190831-15-2) + trans-3-chloro-4,4,5-trimethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole

Guidance literature:

phenyllithium; 3,4,4-trimethyl-5-phenyl-4H-pyrazole;

p-toluenesulfonyl chloride;

DOI:10.1515/HC.2008.14.6.449

Reference yield: 59.0%

4,4,5-trimethyl-3,5-diphenyl-1-(toluene-4-sulfonyl)-4,5-dihydro-1H-pyrazole (1190831-15-2) + methyllithium (917-54-4) → cis-3,4,4,5-tetramethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole (1260633-76-8)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 24.5h; Inert atmosphere;

DOI:10.1002/jhet.266

upstream raw materials:

p-toluenesulfonyl fluoride

phenyllithium

3,4,4-trimethyl-5-phenyl-4H-pyrazole

p-toluenesulfonyl chloride

Downstream raw materials:

cis-3,4,4,5-tetramethyl-3,5-diphenyl-4,5-dihydro-3H-pyrazole

phenyltolylsulfone

3,4,4-trimethyl-3,5,5-triphenyl-4,5-dihydro-3H-pyrazole

4,5-dihydro-4,4,5,5-tetramethyl-3-phenyl-1H-pyrazole

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