N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole

Base Information

Chemical Name:N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole
CAS No.:1401316-07-1
Molecular Formula:C₃₀H₂₃F₃N₂O
Molecular Weight:484.521
Hs Code.:

Synonyms:N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole

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Chemical Property of N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole

Chemical Property:

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Technology Process of N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole

There total 4 articles about N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1041845-46-8
1-benzyl-2-(4-methoxyphenyl)-5-phenyl-1H-imidazole

: 455-13-0
4-Iodobenzotrifluoride

: 1401316-07-1
N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole

Guidance literature:: With [Pd(phen)2](PF₆)2; caesium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 20h;
DOI:10.1021/jo301621t

Reference yield:

: 4238-71-5
1-benzylimidazole

: 1401316-07-1
N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate / N,N-dimethyl acetamide / 150 °C / Inert atmosphere

2: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 4 h / 150 °C

3: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 20 h / 150 °C

With trifuran-2-yl-phosphane; [Pd(phen)2](PF₆)2; palladium diacetate; potassium carbonate; caesium carbonate; In N,N-dimethyl acetamide;
DOI:10.1021/jo301621t

Reference yield:

: 53704-79-3
1-benzyl-5-phenyl-1H-imidazole

: 1401316-07-1
N-benzyl-2-(4-methoxyphenyl)-4-(4-trifluoromethylphenyl)-5-phenylimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 4 h / 150 °C

2: [Pd(phen)2](PF₆)2; caesium carbonate / N,N-dimethyl acetamide / 20 h / 150 °C

With [Pd(phen)2](PF₆)2; caesium carbonate; In N,N-dimethyl acetamide;
DOI:10.1021/jo301621t