4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid

Base Information

• Chemical Name: 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid
• CAS No.: 131524-45-3
• Molecular Formula: C₁₅H₁₃ClO₄
• Molecular Weight: 292.719
• Mol file: 131524-45-3.mol

Synonyms:4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid

Chemical Property of 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid

There total 3 articles about 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-benzyloxy-2-hydroxy-6-methylbenzoic acid (54102-37-3) → 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid (131524-45-3)

Guidance literature:

With sulfuryl dichloride; In diethyl ether; for 22h; Ambient temperature;

DOI:10.1071/CH9950635

Reference yield: 51.0%

ethyl 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoate (131524-44-2) → 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid (131524-45-3)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 98 ℃; for 4h;

DOI:10.1071/CH9901745

Reference yield:

ethyl 4-(benzyloxy)-2-hydroxy-6-methylbenzoate (39503-11-2) → 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid (131524-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / sulfuryl chloride / diethyl ether / 17 h / 17 °C

2: 51 percent / KOH / dimethylsulfoxide / 4 h / 98 °C

With potassium hydroxide; sulfuryl dichloride; In diethyl ether; dimethyl sulfoxide;

DOI:10.1071/CH9901745

upstream raw materials:

ethyl 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoate

4-benzyloxy-2-hydroxy-6-methylbenzoic acid

ethyl 4-(benzyloxy)-2-hydroxy-6-methylbenzoate

Downstream raw materials:

benzyl-4-(4'-benzyloxy-3'-chloro-6'-hydroxy-2'-methoxybenzoyloxy)-2,6-dihydroxybenzoate