Benzoic acid, 2-hydroxy-6-methyl-4-(phenylmethoxy)-

Base Information

• Chemical Name: Benzoic acid, 2-hydroxy-6-methyl-4-(phenylmethoxy)-
• CAS No.: 54102-37-3
• Molecular Formula: C15H14O4
• Molecular Weight: 258.274
• Mol file: 54102-37-3.mol

Synonyms:

Chemical Property of Benzoic acid, 2-hydroxy-6-methyl-4-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2-hydroxy-6-methyl-4-(phenylmethoxy)-

There total 2 articles about Benzoic acid, 2-hydroxy-6-methyl-4-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C18H18O4 → 4-benzyloxy-2-hydroxy-6-methylbenzoic acid (54102-37-3)

Guidance literature:

With trifluoroacetic acid; In water; for 24h;

DOI:10.1016/j.tetlet.2018.10.020

Reference yield:

orsellinic acid (480-64-8) → 4-benzyloxy-2-hydroxy-6-methylbenzoic acid (54102-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic anhydride; trifluoroacetic acid / 24 h / 25 °C

2: sodium hydride / tetrahydrofuran / 6 h / 0 - 25 °C

3: trifluoroacetic acid / water / 24 h

With sodium hydride; trifluoroacetic acid; trifluoroacetic anhydride; In tetrahydrofuran; water;

DOI:10.1016/j.tetlet.2018.10.020

Reference yield: 96.0%

4-benzyloxy-2-hydroxy-6-methylbenzoic acid (54102-37-3) → 4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid (131524-45-3)

Guidance literature:

With sulfuryl dichloride; In diethyl ether; for 22h; Ambient temperature;

DOI:10.1071/CH9950635

upstream raw materials:

orsellinic acid

Downstream raw materials:

4-benzyloxy-2-(9-hydroxy-5-oxononyloxy)-6-methylbenzoic acid lactone

methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate

4-benzyloxy-3-chloro-6-hydroxy-2-methylbenzoic acid

methyl 4-O-benzyl-2'-O-methyllecanorate

Refernces