1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene

Base Information

Chemical Name:1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene
CAS No.:177477-91-7
Molecular Formula:C₃₇H₃₉Cl₂N₃O₄Si
Molecular Weight:688.726
Hs Code.:

Synonyms:1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene

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Chemical Property of 1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene

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Technology Process of 1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene

There total 8 articles about 1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 177477-91-7
1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 81.5 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

3: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

5: 92.6 percent / NH₂-NH₂*H₂O / ethanol / 1 h / Heating

6: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

With 1H-imidazole; WSCD*HCl; iron(III) chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 160647-01-8
2,6-Dichloro-3-nitrobenzyl alcohol

: 177477-91-7
1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 81.5 percent / imidazole / dimethylformamide / 3 h / Ambient temperature

2: FeCl₃*6H₂O, C, NH₂-NH₂*H₂O / methanol; H₂O / 5 h / 70 °C

3: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

4: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

5: 92.6 percent / NH₂-NH₂*H₂O / ethanol / 1 h / Heating

6: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

With 1H-imidazole; WSCD*HCl; iron(III) chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f

Reference yield:

: 167837-45-8
3-amino-1-(tert-butyldiphenylsilyloxymethyl)-2,6-dichlorobenzene

: 177477-91-7
1-(tert-Butyldiphenylsilyloxymethyl)-2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl) cinnamoylglycyl]amino]-benzene

Guidance literature:: Multi-step reaction with 4 steps

1: 89.3 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 - 20 °C

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 2 h

3: 92.6 percent / NH₂-NH₂*H₂O / ethanol / 1 h / Heating

4: WSCD*HCl, HOBt / dimethylformamide / 2 h / Ambient temperature

With WSCD*HCl; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980300f