5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide

Base Information

Chemical Name:5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide
CAS No.:1314023-94-3
Molecular Formula:C₂₀H₁₇F₃N₂O₂
Molecular Weight:374.362
Hs Code.:

Synonyms:5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide

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Chemical Property of 5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide

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Technology Process of 5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide

There total 4 articles about 5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 668970-85-2
5-(4-trifluoromethyl-phenyl)-isoxazole-3-carboxylic acid

: 2038-57-5
3-Phenylpropan-1-amine

: 1314023-94-3
5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide

Guidance literature:: 5-(4-trifluoromethyl-phenyl)-isoxazole-3-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.75h;

3-Phenylpropan-1-amine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2011.04.057

Reference yield:

: 709-63-7
1-(4-trifluoromethylphenyl)ethanone

: 1314023-94-3
5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium ethanolate / ethanol / 2 h / Reflux

1.2: 1 h

2.1: hydroxylamine hydrochloride / ethanol / 2 h / Reflux

3.1: sodium hydroxide / ethanol / 24 h / 20 °C

3.2: pH 2

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C

4.2: 24 h / 20 °C

With hydroxylamine hydrochloride; sodium ethanolate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane; 1.1: Claisen condensation;
DOI:10.1016/j.bmc.2011.04.057

Reference yield:

: 613240-18-9
5-(4-Trifluoromethyl-phenyl)-isoxazole-3-carboxylic Acid Ethyl Ester

: 1314023-94-3
5-(4-(trifluoromethyl)phenyl)-N-(3-phenylpropyl)isoxazole-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 24 h / 20 °C

1.2: pH 2

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 20 °C

2.2: 24 h / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2011.04.057