2-Aminododecanoic acid

Base Information

• Chemical Name: 2-Aminododecanoic acid
• CAS No.: 35237-37-7
• Molecular Formula: C12H25 N O2
• Molecular Weight: 215.336
• Hs Code.: 2922499990
• European Community (EC) Number: 252-454-6
• NSC Number: 206262
• DSSTox Substance ID: DTXSID20956676
• Nikkaji Number: J360.085H
• Mol file: 35237-37-7.mol

Synonyms:2-aminododecanoic acid;35237-37-7;alpha-aminolauric acid;(1)-2-Aminododecanoic acid;(2S)-2-Amino-dodecanoic acid;EINECS 252-454-6;2-amino-dodecanoic acid;DL-2-Aminododecanoic acid;dodecyline;aminododecanoic acid;2-aminododecanoicacid;2-Amino-dodecanoicacid;SCHEMBL127959;(+-)-2-aminododecanoic acid;DTXSID20956676;AMY22040;MFCD00020390;NSC206262;AKOS011504674;AB87088;AB88434;NSC-206262;DS-18374;CS-0152253;FT-0722824;2-Aminododecanoic acid (H-DL-Nle(hexyl)-OH);C74815

Chemical Property of 2-Aminododecanoic acid

Chemical Property:

• Melting Point: 263 °C (decomp)
• Boiling Point: 332.8±25.0 °C(Predicted)
• PKA: 2.55±0.24(Predicted)
• PSA: 63.32000
• Density: 0.955
• LogP: 3.62940
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 10
• Exact Mass: 215.188529040
• Heavy Atom Count: 15
• Complexity: 160

Purity/Quality:

99.9% ^*data from raw suppliers

2-Aminododecanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCC(C(=O)O)N

Technology Process of 2-Aminododecanoic acid

There total 12 articles about 2-Aminododecanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl N-(trifluoroacetyl)-2-aminododecanoate (129592-92-3) → 2-amino-dodecanoic acid (35237-37-7)

Guidance literature:

With potassium hydroxide; In methanol; for 2h; Ambient temperature;

DOI:10.1021/jo00001a077

Reference yield: 66.0%

2-bromododecanoic acid (111-56-8,201417-52-9) → 2-amino-dodecanoic acid (35237-37-7)

Guidance literature:

With ammonium hydroxide; for 168h; Ambient temperature;

DOI:10.1021/jm00398a027

Reference yield:

ethyl 2-bromododecanoate (6974-87-4) → 2-amino-dodecanoic acid (35237-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / K₂CO₃ / benzyltriethylammonium chloride / acetonitrile / 3.5 h / Heating

2: 100 percent / 20percent aq. KOH / methanol / 2 h / Ambient temperature

With potassium hydroxide; potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride; In methanol; acetonitrile;

DOI:10.1021/jo00001a077

upstream raw materials:

2-bromododecanoic acid

Acetamino-decyl-malonsaeure-diaethylester

ethyl N-(trifluoroacetyl)-2-aminododecanoate

2-(2,2,2-Trifluoro-acetylamino)-dodecanoic acid tert-butyl ester

Downstream raw materials:

(+/-)-2-Acetamino-dodecansaeure-(1)

C₁₂H₂₅NO₂*C₁₈H₃₇N₅O₉

(+/-)-p-nitrophenyl N-(benzyloxycarbonyl)-α-aminododecanoic acid

(S)-2-{[2-(2-Amino-3-hydroxy-propyl)-phenyl]-methyl-amino}-dodecanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

Refernces

• 1、 Parekh, Harendra S.,Marano, Robert J.,Rakoczy, Elizabeth P.,Blanchfield, Joanne,Toth, Istvan. "Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition". . p. 4775 - 4780. Retrieved 2007/10/03.
• 2、 Koide, Yoshifumi,Tsujimoto, Keigo,Shosenji, Hideto,Maeda, Mizuo,Takagi, Makoto. "Adsorption of Metal Ions to Surface-Template Resins Prepared with Amphiphilic Styrene Monomers Bearing Amino Carboxylic Acid". . p. 789 - 796. Retrieved 2007/10/03.