3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid

Base Information

Chemical Name:3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid
CAS No.:1392842-72-6
Molecular Formula:C₂₇H₂₅N₃O₅
Molecular Weight:471.513
Hs Code.:

Synonyms:3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid

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Chemical Property of 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid

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Technology Process of 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid

There total 7 articles about 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-58-5
3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

: 1392842-72-6
3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 100-46-9
benzylamine

: 1392842-72-6
3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: sodium methylate / methanol / 5 h

6.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

7.1: ethanol / 6 h / 140 °C / microwave Irradiation

8.1: trifluoroacetic acid / dichloromethane / 2 h

With N-Bromosuccinimide; sodium methylate; potassium carbonate; trifluoroacetic acid; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1392838-68-4
1-benzyl-3-bromo-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 1392842-72-6
3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

2: ethanol / 6 h / 140 °C / microwave Irradiation

3: trifluoroacetic acid / dichloromethane / 2 h

With trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;