3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

Base Information

Chemical Name:3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester
CAS No.:1392839-58-5
Molecular Formula:C₃₁H₃₃N₃O₅
Molecular Weight:527.62
Hs Code.:

Synonyms:3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

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Chemical Property of 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

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Technology Process of 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

There total 6 articles about 3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25307-82-8
methyl 3-amino-2,2-dimethylpropionate

: 1392838-76-4
1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]-naphthyridine-6-carboxylic acid methyl ester

: 1392839-58-5
3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

Guidance literature:: In ethanol; at 140 ℃; for 6h; microwave Irradiation;

Reference yield:

: 100-46-9
benzylamine

: 1392839-58-5
3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

5.1: sodium methylate / methanol / 5 h

6.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

7.1: ethanol / 6 h / 140 °C / microwave Irradiation

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 420087-95-2
4-(1-benzylamino-ethylidene)-pent-2-enedioic acid dimethyl ester

: 1392839-58-5
3-[(1-benzyl-5-hydroxy-2-oxo-3-phenyl-1,2-dihydro-[1,7]naphthyridine-6-carbonyl)-amino]-2,2-dimethyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 72 h / 20 °C

4: sodium methylate / methanol / 5 h

5: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 120 °C / Inert atmosphere

6: ethanol / 6 h / 140 °C / microwave Irradiation

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; bis-triphenylphosphine-palladium(II) chloride; In methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;