[5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone

Base Information

• Chemical Name: [5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone
• CAS No.: 1255940-22-7
• Molecular Formula: C₂₀H₁₈O₃S
• Molecular Weight: 338.427
• Mol file: 1255940-22-7.mol

Synonyms:[5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone

Chemical Property of [5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone

There total 2 articles about [5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

→ [5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone (1255940-22-7)

Guidance literature:

Reference yield:

3-ethyl-4-methoxybenzene boronic acid (947547-41-3) + (5-bromothiophene-2-yl)(3-hydroxyphenyl)methanone (1226341-15-6) → [5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone (1255940-22-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,2-dimethoxyethane; water; for 2h; Reflux; Inert atmosphere;

DOI:10.1021/jm101073q

Reference yield: 47.0%

[5-(3-ethyl-4-methoxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone (1255940-22-7) → [5-(3-ethyl-4-hydroxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone (1255940-00-1)

Guidance literature:

With pyridine hydrochloride; at 220 ℃; for 18h;

DOI:10.1021/jm101073q

upstream raw materials:

3-ethyl-4-methoxybenzene boronic acid

(5-bromothiophene-2-yl)(3-hydroxyphenyl)methanone

Downstream raw materials:

[5-(3-ethyl-4-hydroxyphenyl)-2-thienyl](3-hydroxyphenyl)methanone