benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride

Base Information

• Chemical Name: benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride
• CAS No.: 949495-21-0
• Molecular Formula: C₁₆H₂₂N₂O₃*ClH
• Molecular Weight: 326.823

Synonyms:benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride

Chemical Property of benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride

Chemical Property:

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Technology Process of benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride

There total 1 articles about benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate (949495-20-9) → benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride (949495-21-0)

Guidance literature:

With hydrogenchloride; In methanol; ethyl acetate; at 20 ℃;

Reference yield: 100.0%

benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride (949495-21-0) + benzyl bromide (100-39-0) → benzyl (3R,4S)-3-(N-benzyl-N-cyclopropyl)aminomethyl-4-hydroxypyrrolidine-1-carboxylate (949495-22-1)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; at 40 - 45 ℃; for 3h;

Reference yield: 99.0%

benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate hydrochloride (949495-21-0) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl (3S,4S)-3-(N-benzyloxycarbonyl-N-cyclopropyl)aminomethyl-4-hydroxypyrrolidine-1-carboxylate (949495-24-3)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; at 20 ℃; for 8h;

upstream raw materials:

benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

Downstream raw materials:

benzyl (3R,4S)-3-(N-benzyl-N-cyclopropyl)aminomethyl-4-hydroxypyrrolidine-1-carboxylate

benzyl (3S,4S)-3-(N-tert-butoxycarbonyl-N-cyclopropyl)aminomethyl-4-hydroxypyrrolidine-1-carboxylate

benzyl (3S,4S)-3-(N-benzyloxycarbonyl-N-cyclopropyl)aminomethyl-4-hydroxypyrrolidine-1-carboxylate

benzyl (3R,4S)-3-((cyclopropylamino)methyl)-4-hydroxypyrrolidine-1-carboxylate

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