4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene

Base Information

• Chemical Name: 4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene
• CAS No.: 954383-27-8
• Molecular Formula: C₂₀H₂₈O₂
• Molecular Weight: 300.441
• Mol file: 954383-27-8.mol

Synonyms:4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene

Chemical Property of 4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene

There total 2 articles about 4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3,5-di-tert-butyl-2-(propen-3-yloxy)benzaldehyde (153034-24-3) + acetylenemagnesium bromide (4301-14-8) → 4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene (954383-27-8)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2017.08.053

Reference yield:

3,5-di-tert-butyl-2-hydroxybenzaldehyde (37942-07-7) → 4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene (954383-27-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / K₂CO₃ / dimethylformamide / 20 °C

2: 75 percent / tetrahydrofuran / 0 °C

With potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1055/s-2007-984880

Reference yield: 99.0%

4,6-di-tert-butyl-2-(1-hydroxy-2-propynyl)-(2-propenyloxy)benzene (954383-27-8) + tert-butyldimethylsilyl chloride (18162-48-6) → 4,6-di-tert-butyl-2-(1-tert-butyldimethylsilyloxy-2-propynyl)-(2-propenyloxy)benzene (954383-39-2)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 - 50 ℃; for 4.5h;

DOI:10.1016/j.tet.2017.08.053

upstream raw materials:

3,5-di-tert-butyl-2-(propen-3-yloxy)benzaldehyde

acetylenemagnesium bromide

3,5-di-tert-butyl-2-hydroxybenzaldehyde

Downstream raw materials:

4,6-di-tert-butyl-2-(1-tert-butyldimethylsilyloxy-2-propynyl)-(2-propenyloxy)benzene