triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate

Base Information

• Chemical Name: triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate
• CAS No.: 1315594-40-1
• Molecular Formula: C₃₃H₂₆N₂O₇
• Molecular Weight: 562.579
• Mol file: 1315594-40-1.mol

Synonyms:triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate

Chemical Property of triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate

There total 2 articles about triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2-(1H-perimidin-2(3H)-ylidene)-1-phenylethan-1-one (1315594-32-1) + acetylenedicarboxylic acid diethyl ester (762-21-0) → triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate (1315594-40-1)

Guidance literature:

With dmap; In ethyl acetate; for 0.5h; Reflux;

DOI:10.1016/j.tet.2011.05.078

Reference yield:

naphthalene-1,8-diamine (479-27-6) → triethyl 12-oxo-8-phenyl-12H-isoindolo[2,1-a]perimidine-9,10,11-tricarboxylate (1315594-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 5 h / Reflux

2: dmap / ethyl acetate / 0.5 h / Reflux

With dmap; toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate;

DOI:10.1016/j.tet.2011.05.078

upstream raw materials:

2-(1H-perimidin-2(3H)-ylidene)-1-phenylethan-1-one

acetylenedicarboxylic acid diethyl ester

naphthalene-1,8-diamine