2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide

Base Information

• Chemical Name: 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide
• CAS No.: 1207961-56-5
• Molecular Formula: C₁₆H₁₅Cl₂F₂N₅O₂
• Molecular Weight: 418.23

Synonyms:2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide

Chemical Property of 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide

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Technology Process of 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide

There total 1 articles about 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

(2,4-dichloro-6-hydroxyphenyl)boronic acid (1028332-22-0) + C10H12F2IN5O (1207961-57-6) → 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide (1207961-56-5)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 85 ℃; for 3h; Inert atmosphere;

Reference yield: 33.0%

methanesulfonic acid 2-(4-fluoropyrazol-1-yl)ethyl ester (1207961-58-7) + 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide (1207961-56-5) → 2-amino-4-{2,4-dichloro-6-[2-(4-fluoropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoropropyl)amide (1207961-30-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; microwave irradiation;

Reference yield: 20.0%

1-(2-chloro-ethyl)-1H-pyrazole-4-carbonitrile (1207961-63-4) + 2-amino-4-(2,4-dichloro-6-hydroxy-phenyl)-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoro propyl)-amide (1207961-56-5) → 2-amino-4-{2,4-dichloro-6-[2-(4-cyano-1H-pyrazol-1-yl)ethoxy]phenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide (1207961-35-0)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 90 ℃; for 12h;

upstream raw materials:

(2,4-dichloro-6-hydroxyphenyl)boronic acid

C₁₀H₁₂F₂IN₅O

Downstream raw materials:

2-amino-4-{2,4-dichloro-6-[2-(4-fluoropyrazol-1-yl)ethoxy]phenyl}-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylic acid (2,2-difluoropropyl)amide

2-amino-4-{2,4-dichloro-6-[2-(4-cyano-1H-pyrazol-1-yl)ethoxy]phenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

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