methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate

Base Information

• Chemical Name: methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate
• CAS No.: 1190211-36-9
• Molecular Formula: C₁₆H₂₀O₃
• Molecular Weight: 260.333
• Mol file: 1190211-36-9.mol

Synonyms:methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate

Chemical Property of methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate

There total 5 articles about methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 2-(o-iodobenzyl)-4-oxo-pentanoate (290818-02-9) → methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate (1190211-36-9)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 70 ℃; for 4h;

DOI:10.1055/s-0029-1217520

Reference yield: 89.0%

methyl 2-(o-iodobenzyl)-4-oxo-pentanoate (290818-02-9) + potassium isopropenyltrifluoroborane → methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate (1190211-36-9)

Guidance literature:

With palladium diacetate; caesium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 70 ℃; for 5h; Inert atmosphere; Sealed vessel;

DOI:10.3762/bjoc.6.141

Reference yield:

2-Methyl-2-(trimethylsiloxy)cyclopropancarbonsaeure-methylester (77903-43-6) → methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate (1190211-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 36 h / -78 °C / Inert atmosphere

2.1: triethylamine tris(hydrogen fluoride) / dichloromethane / 12 h / 20 °C / Inert atmosphere

3.1: palladium diacetate; caesium carbonate; triphenylphosphine / tetrahydrofuran; water / 5 h / 70 °C / Inert atmosphere; Sealed vessel

With palladium diacetate; caesium carbonate; triethylamine tris(hydrogen fluoride); triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water;

DOI:10.3762/bjoc.6.141

upstream raw materials:

methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate

2-iodobenzyliodide

2-Methyl-2-(trimethylsiloxy)cyclopropancarbonsaeure-methylester

methyl 2-(o-iodobenzyl)-4-oxo-pentanoate