methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate

Base Information

• Chemical Name: methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate
• CAS No.: 1260498-77-8
• Molecular Formula: C₁₆H₂₃IO₃Si
• Molecular Weight: 418.347
• Mol file: 1260498-77-8.mol

Synonyms:methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate

Chemical Property of methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate

There total 1 articles about methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-iodobenzyliodide (4622-38-2) + 2-Methyl-2-(trimethylsiloxy)cyclopropancarbonsaeure-methylester (77903-43-6) → methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate (1260498-77-8)

Guidance literature:

2-Methyl-2-(trimethylsiloxy)cyclopropancarbonsaeure-methylester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

2-iodobenzyliodide; In tetrahydrofuran; at -78 ℃; for 36h; Inert atmosphere;

DOI:10.3762/bjoc.6.141

Reference yield: 84.0%

methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate (1260498-77-8) → methyl 2-(o-iodobenzyl)-4-oxo-pentanoate (290818-02-9)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.3762/bjoc.6.141

Reference yield:

methyl 1-(2-iodobenzyl)-2-methyl-2-trimethylsiloxycyclopropane carboxylate (1260498-77-8) → methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate (1190211-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine tris(hydrogen fluoride) / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: palladium diacetate; caesium carbonate; triphenylphosphine / tetrahydrofuran; water / 5 h / 70 °C / Inert atmosphere; Sealed vessel

With palladium diacetate; caesium carbonate; triethylamine tris(hydrogen fluoride); triphenylphosphine; In tetrahydrofuran; dichloromethane; water;

DOI:10.3762/bjoc.6.141

upstream raw materials:

2-iodobenzyliodide

2-Methyl-2-(trimethylsiloxy)cyclopropancarbonsaeure-methylester

Downstream raw materials:

methyl 2-(2-isopropenylbenzyl)-4-oxopentanoate

methyl 4-oxo-2-{2-[(1E)-propen-1-yl]benzyl}pentanoate

methyl 2-[2-(2-methylpropen-1-yl)benzyl]-4-oxopentanoate

methyl 2-(o-iodobenzyl)-4-oxo-pentanoate