3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester

Base Information

• Chemical Name: 3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester
• CAS No.: 143330-95-4
• Molecular Formula: C₅₈H₄₉Cl₃O₁₀
• Molecular Weight: 1012.38
• Mol file: 143330-95-4.mol

Synonyms:3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester

Chemical Property of 3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester

There total 2 articles about 3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

3,5-bis[3,5-bis(benzyloxy)benzyloxy]benzyl bromide (129536-41-0) + 2',2',2'-trichloroethyl 3,5-dihydroxybenzoate (143330-91-0) → 3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester (143330-95-4)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 24h; Heating;

DOI:10.1021/ja00048a009

Reference yield:

3,5-Dihydroxybenzoic acid (99-10-5) → 3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester (143330-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 61.4 percent / conc. H₂SO₄ / 48 h / 90 °C

2: 46 percent / K₂CO₃, 18-crown-6 / acetone / 24 h / Heating

With 18-crown-6 ether; sulfuric acid; potassium carbonate; In acetone;

DOI:10.1021/ja00048a009

Reference yield:

HO2CC6H3(OC(O)C6H3(OC(O)C6H5)2)2 (143345-04-4) + 3-[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-benzyloxy]-5-hydroxy-benzoic acid 2,2,2-trichloro-ethyl ester (143330-95-4) → C107H77Cl3O23 (143345-07-7)

Guidance literature:

With dicyclohexyl-carbodiimide; 4-(dimethylamino)pyridinium tosylate; Yield given. Multistep reaction; 1.) CH₂Cl₂, RT, 15 min, 2.) CH₂Cl₂, RT, 15 min;

DOI:10.1021/ja00048a009

upstream raw materials:

3,5-bis[3,5-bis(benzyloxy)benzyloxy]benzyl bromide

2',2',2'-trichloroethyl 3,5-dihydroxybenzoate

3,5-Dihydroxybenzoic acid

Downstream raw materials:

C₁₀₇H₇₇Cl₃O₂₃