Technology Process of 2-((2-(2-(trifluoromethyl)phenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid
There total 7 articles about 2-((2-(2-(trifluoromethyl)phenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C21H25F3N2O5S;
With
water; sodium hydroxide;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 2h;
With
potassium hydrogensulfate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: water; potassium hydroxide / Reflux
2.1: triethylamine / dichloromethane / 0 - 20 °C
3.1: trifluoroacetic acid / 20 °C / Cooling with ice
4.1: methanol; sodium tetrahydroborate / water / 1.17 h / 0 °C
5.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
6.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere
6.2: 20 °C
7.1: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water / 3 h / 20 °C
8.1: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
With
methanol; sodium tetrahydroborate; lithium borohydride; tetrabutyl-ammonium chloride; water; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C
1.2: 12 h / 20 °C
2.1: trifluoroacetic acid / 20 °C / Cooling with ice
3.1: methanol; sodium tetrahydroborate / water / 1.17 h / 0 °C
4.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: lithium borohydride / tetrahydrofuran / 20 °C / Inert atmosphere
5.2: 20 °C
6.1: tetrabutyl-ammonium chloride; sodium hydroxide / dichloromethane; water / 3 h / 20 °C
7.1: water; sodium hydroxide / tetrahydrofuran; methanol / 2 h / 20 °C
With
methanol; sodium tetrahydroborate; lithium borohydride; 1-hydroxy-7-aza-benzotriazole; tetrabutyl-ammonium chloride; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water;
