6-methoxy-2-phenyl-1-benzofuran

Base Information

• Chemical Name: 6-methoxy-2-phenyl-1-benzofuran
• CAS No.: 33973-14-7
• Molecular Formula: C₁₅H₁₂O₂
• Molecular Weight: 224.259
• Mol file: 33973-14-7.mol

Synonyms:6-methoxy-2-phenyl-1-benzofuran

Chemical Property of 6-methoxy-2-phenyl-1-benzofuran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-methoxy-2-phenyl-1-benzofuran

There total 34 articles about 6-methoxy-2-phenyl-1-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(2-hydroxy-4-methoxyphenyl)-1-phenyl-1-ethanone (1018669-02-7) → 6-methoxy-2-phenyl-1-benzofuran (33973-14-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane;

DOI:10.1016/j.tet.2008.01.024

Reference yield: 93.0%

2-iodo-5-methoxyphenol (41046-70-2) + phenylacetylene (536-74-3) → 6-methoxy-2-phenyl-1-benzofuran (33973-14-7)

Guidance literature:

With copper(l) iodide; L-proline; sodium hydroxide; In dimethyl sulfoxide; at 80 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2018.11.076

Reference yield: 92.0%

2-hydroxy-4-methoxyphenylacetonitrile (32884-26-7) + potassium phenyltrifluoborate → 6-methoxy-2-phenyl-1-benzofuran (33973-14-7)

Guidance literature:

With [2,2]bipyridinyl; palladium(II) trifluoroacetate; water; trifluoroacetic acid; In tetrahydrofuran; at 80 ℃; for 36h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo400433m

upstream raw materials:

2-Hydroxy-4-methoxybenzaldehyde

ethyl 2-phenyl-2-bromoacetate

2-(4-methoxyphenyl)acetophenone

(E)-2,4-dimethoxy-α-phenylcinnamic acid

Downstream raw materials:

<6-methoxy-2-phenyl-1-benzofuran-3-yl>(4-methoxyphenyl)methanone

(6-hydroxy-2-phenyl-1-benzofuran-3-yl)(4-hydroxyphenyl)methanone

6-hydroxy-2-phenylbenzofuran