Ethyl bromophenylacetate

Base Information

• Chemical Name: Ethyl bromophenylacetate
• CAS No.: 2882-19-1
• Molecular Formula: C10H11BrO2
• Molecular Weight: 243.1
• Hs Code.: 29163990
• European Community (EC) Number: 218-701-7,220-735-2
• NSC Number: 38807
• UNII: 0N3C9JY41X
• DSSTox Substance ID: DTXSID8041951
• Nikkaji Number: J62.890E
• Wikidata: Q27236983
• ChEMBL ID: CHEMBL3187649
• Mol file: 2882-19-1.mol

Synonyms:2882-19-1;Ethyl alpha-bromophenylacetate;ethyl 2-bromo-2-phenylacetate;Ethyl bromophenylacetate;2216-90-2;Ethyl bromo(phenyl)acetate;Benzeneacetic acid, .alpha.-bromo-, ethyl ester;UNII-0N3C9JY41X;alpha-bromobenzeneacetic acid ethyl ester;Ethyl (1)-bromophenylacetate;Ethyl-alpha-bromophenyl acetate;0N3C9JY41X;DTXSID8041951;Benzeneacetic acid, alpha-bromo-, ethyl ester;Ethyl-.alpha.-bromophenyl acetate;EINECS 218-701-7;EINECS 220-735-2;NSC-38807;Acetic acid, bromophenyl-, ethyl ester;ETHYL 2-BROMO-2-PHENYL-ACETATE;bromo-phenyl-acetic acid ethyl ester;ethyl -bromophenylacetate;ethyl bromo-phenylacetate;ethyl a-bromophenylacetate;Ethyl bromo(phenyl)acetate #;ethyl-alpha-bromophenylacetate;SCHEMBL280401;Ethyl alpha-bromobenzeneacetate;2-o-Tolylethanesulfonylchloride;Ethyl (+-)-bromophenylacetate;Ethyl alpha -bromophenylacetate;CHEMBL3187649;DTXCID6021951;Ethyl .alpha.-bromophenylacetate;Bromophenylacetic acid ethyl ester;NSC38807;Tox21_301444;Ethyl alpha-bromophenylacetate, 97%;MFCD00013536;NSC 38807;AKOS005068226;Benzeneacetic acid,a-bromo-,ethyl ester;2-Bromo-2-phenylacetic acid ethyl ester;NCGC00255882-01;AS-48708;CAS-2882-19-1;ETHYL BROMOPHENYLACETATE, (+/-)-;FT-0626159;A18578;EN300-160259;F52714;ETHYL (+/-)-.ALPHA.-BROMOBENZENEACETATE;ETHYL (+/-)-.ALPHA.-BROMOPHENYLACETATE;W-107027;DL-.ALPHA.-BROMOPHENYLACETIC ACID ETHYL ESTER;Q27236983

Chemical Property of Ethyl bromophenylacetate

Chemical Property:

• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: n20/D >1.5390(lit.)
• Boiling Point: 268.4 °C at 760 mmHg
• Flash Point: 116.1 °C
• PSA: 26.30000
• Density: 1.407 g/cm³
• LogP: 2.68570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Moisture Sensitive
• Water Solubility.: Not miscible or difficult to mix in water.
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 241.99424
• Heavy Atom Count: 13
• Complexity: 164

Purity/Quality:

97% ^*data from raw suppliers

α-BromobenzeneaceticAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C1=CC=CC=C1)Br
• Uses: ETHYL ALPHA-BROMOPHENYLACETATE is used as an alkyl halide initiator in controlled/living radical polymerization of styrene and methyl methacrylate. α-Bromobenzeneacetic acid ethyl ester is used as an alkyl halide initiator in controlled/living radical polymerization of styrene and methyl methacrylate.

Technology Process of Ethyl bromophenylacetate

There total 24 articles about Ethyl bromophenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Ethyl 2-phenylethanoate (101-97-3) → ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 8h; Inert atmosphere; Reflux;

DOI:10.1021/ol402385v

Reference yield: 99.0%

2-bromophenylacetic acid (4870-65-9,31302-84-8) + ethanol (64-17-5) → ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 2h;

DOI:10.1002/anie.201809333

Reference yield: 89.0%

ethyl 2-phenyldiazoacetate (22065-57-2) → ethyl 2-phenyl-2-bromoacetate (2882-19-1,2216-90-2)

Guidance literature:

With cobalt(II) bromide hexahydrate; In 1,4-dioxane; at 100 ℃; for 1h; Reagent/catalyst; Solvent; Mechanism; Inert atmosphere;

DOI:10.1002/adsc.202000009

upstream raw materials:

phenylacetic acid

2-bromophenylacetic acid

ethanol

bromo(phenyl)acetyl chloride

Downstream raw materials:

ethyl 2-phenyl-2-(piperidin-1-yl)acetate

α-morpholine ethyl phenylacetate

(+/-)-α-<4-Methyl-piperazyl-(1)>-phenylessigsaeure-aethylester

6-methoxy-2-phenyl-1-benzofuran