9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid

Base Information

• Chemical Name: 9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid
• CAS No.: 168844-74-4
• Molecular Formula: C₇₁H₈₇NO₁₆
• Molecular Weight: 1210.47
• Mol file: 168844-74-4.mol

Synonyms:9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid

Chemical Property of 9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid

There total 2 articles about 9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-2-(9-oxo-nonyloxy)-tetrahydro-pyran-3-yl]-acetamide → 9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid (168844-74-4)

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; Yield given;

DOI:10.1021/ja00142a008

Reference yield:

N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide (847231-64-5) → 9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid (168844-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, 2.) CH₂Cl₂

2: NaClO₂, NaH₂PO₄*H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In water; tert-butyl alcohol;

DOI:10.1021/ja00142a008

upstream raw materials:

N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide