N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide

Base Information

• Chemical Name: N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide
• CAS No.: 847231-64-5
• Molecular Formula: C₇₁H₈₉NO₁₅
• Molecular Weight: 1196.49
• Mol file: 847231-64-5.mol

Synonyms:N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide

Chemical Property of N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide

There total 1 articles about N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C87H107NO15Si → N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide (847231-64-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/ja00142a008

Reference yield:

N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide (847231-64-5) → 9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid (168844-74-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) oxalyl chloride, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, 2.) CH₂Cl₂

2: NaClO₂, NaH₂PO₄*H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In water; tert-butyl alcohol;

DOI:10.1021/ja00142a008

Reference yield:

N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-2-(9-hydroxy-nonyloxy)-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-3-yl]-acetamide (847231-64-5) → N-[(2R,3R,4R,5R)-5-[(2S,3R,5R,6R)-5-Benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-2-(9-oxo-nonyloxy)-tetrahydro-pyran-3-yl]-acetamide

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; Multistep reaction; 1.) CH₂Cl₂, 2.) CH₂Cl₂;

DOI:10.1021/ja00142a008

Downstream raw materials:

9-[(2R,3R,4R,5R)-3-Acetylamino-5-[(2S,3R,5R,6R)-5-benzyloxy-6-benzyloxymethyl-3-((2S,3S,4R,5R,6S)-3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy]-4-(4-methoxy-benzyloxy)-tetrahydro-pyran-2-yloxy]-nonanoic acid