1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole

Base Information

• Chemical Name: 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole
• CAS No.: 150403-80-8
• Molecular Formula: C₂₈H₃₅N₃O₂
• Molecular Weight: 445.605
• Mol file: 150403-80-8.mol

Synonyms:1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole

Chemical Property of 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole

There total 3 articles about 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>amino>-1,2,2a,3,4,5-hexahydrobenzindole (150403-79-5) → 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole (150403-80-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;

DOI:10.1021/jm00070a011

Reference yield:

N-cyclohexyl acrylamide (3066-72-6) → 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole (150403-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92.6 percent / butan-1-ol / 72 h / Heating

2: 96 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol; butan-1-ol;

DOI:10.1021/jm00070a011

Reference yield:

(-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine (132619-30-8) → 1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>methylamino>-1,2,2a,3,4,5-hexahydrobenzindole (150403-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 92.6 percent / butan-1-ol / 72 h / Heating

2: 96 percent / H₂ / 10percent Pd/C / ethanol / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol; butan-1-ol;

DOI:10.1021/jm00070a011

upstream raw materials:

formaldehyd

1-benzoyl-4-<<2-(cyclohexylcarbamoyl)ethyl>amino>-1,2,2a,3,4,5-hexahydrobenzindole

N-cyclohexyl acrylamide

(-)-1-Benzoyl-1,2,2a,3,4,5-hexahydrobenzindol-4-amine

Downstream raw materials:

N-Cyclohexyl-3-((2aS,4R)-1,2,2a,3,4,5-hexahydro-benzo[cd]indol-4-yl-methyl-amino)-propionamide

4-{[2-(cyclohexylcarbamoyl)ethyl]methylamino}-1,3,4,5-tetrahydrobenz(cd)indole